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Novel medication more effective for patients with relapsed blood cancer

Furthermore, the precise immunological study demonstrated how a novel medicine increased anti-cancer activity via altering immune cells.
05:58 AM Jul 19, 2024 IST | IANS
novel medication more effective for patients with relapsed blood cancer
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New Delhi, July 18: The hematopoietic cell transplant team at Osaka Metropolitan University Graduate School of Medicine has developed a novel technique based on a new drug combination that has shown considerable anti-cancer activity with low toxicity for relapsed/refractory acute myeloid leukemia (AML) patients.

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Furthermore, the precise immunological study demonstrated how a novel medicine increased anti-cancer activity via altering immune cells.

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Relapsed/refractory acute myeloid leukemia, also known as blood cancer, has an extremely poor prognosis due to resistance to anticancer medicines and the patient's organ function. Allogeneic hematopoietic cell transplantation is a method of anti-tumour immunotherapy that can have an anti-cancer impact but is associated with substantial toxicity.

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It is frequently used for patients who are difficult to treat with chemotherapy but still relapse.

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In research published in the Nature-affiliated Blood Cancer Journal, the researchers describe their clinical observational analysis of 12 patients with AML who relapsed following allogeneic hematopoietic cell transplantation and were treated with venetoclax and azacitidine.

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Venetoclax, an oral medication approved by the FDA in October 2020 for AML, shows promising results in older, untreated AML patients by inhibiting the BCL-2 protein to promote cancer cell death.

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A study by OMU researchers demonstrated significantly better one-year survival rates for the venetoclax combination therapy group (66.7 per cent) compared to a control group (27.3 per cent). Immunological studies revealed that venetoclax-induced immune cell alterations enhanced anti-tumor activity.

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Dr Mitsutaka Nishimoto highlighted the potential of this novel therapy to improve the prognosis of relapsed/refractory AML and reduce treatment burdens, aiming for safer and more effective treatments.

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